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The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains

20 Jul 2015

Abstract excerpt

The human and mouse antibody repertoires are formed by identical processes, but like all small animals, mice only have sufficient lymphocytes to express a small part of the potential antibody repertoire. In this study, we determined how the heavy chain repertoires of two mouse strains are generated. Analysis of IgM- and IgG-associated VDJ rearrangements generated by high-throughput sequencing confirmed the...

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PMID: 26194750
DOI: 10.1098/rstb.2014.0236

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