Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes.

doi:10.1002/eji.1830241151

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Article

Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes.

European journal of immunology - 1 Nov 1994

González-Fernández A, Gilmore D, Milstein C

Abstract excerpt

Somatic hypermutation of immunoglobulin genes and the generation of memory B cells seems to take place in germinal centers, which are chronically present in Peyer's patches. Age-associated changes in the germinal center B cell compartment of Peyer's patches and in the mutations of a kappa light c...

Topics

Aging
Animals
B-Lymphocytes
Base Sequence
Genes, Immunoglobulin
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Molecular Sequence Data
Mutation
Peyer's Patches

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