Article
Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.
BMC immunology - 18 Jan 2011
Lee Young-Kwan, Chiu Sophia, Chew Alex, Greenhalgh David G, Cho Kiho
Abstract excerpt
BACKGROUND: Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a crucial role in T cell selection in the thymus in a T cell receptor (TCR) Vβ-specific manner and SAgs presented by B cells activate T cells in the periphery. The peripheral T cell repertoire is dynamically shaped by the steady induction of T cell tolerance against self antigens throughout the lifespan. We hypothesize that de novo...
Topics
- Animals
- Base Sequence
- Chromosomes, Mammalian
- DNA, Complementary
- Female
- Genes, Viral
- Genetic Loci
- Genome
- Immune System
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Mammary Tumor Virus, Mouse
- Mice