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Article

Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation.

Endocrinology - 1 Aug 1997

Chesneau V, Perlman R K, Li W, Keller G A, Rosner M R

Abstract excerpt

Although considerable evidence implicates insulin-degrading enzyme (IDE) in the cellular metabolism of insulin in many cell types, its mechanism and site of action are not clear. In this study, we have examined the relationship between insulin-degrading enzyme's peroxisomal location and its ability to degrade insulin by mutation of its peroxisomal targeting signal (PTS), the carboxy terminal A/S-K-L tripeptide....

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Source

Identifiers

PMID: 9231799
DOI: 10.1210/endo.138.8.5344

Genes

IDE
PTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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