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Article

The NPEY sequence is not necessary for endocytosis and processing of insulin-receptor complexes.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 1991

Berhanu P, Ibrahim-Schneck R H, Anderson C, Wood W M

Abstract excerpt

The tetrameric amino acid sequence AsnProXTyr (NPXY), where X represents any amino acid, is conserved in the intracytoplasmic domains of several membrane proteins and has been postulated to play a role in receptor-mediated endocytosis. The human insulin receptor (hIR) contains a single copy of the sequence AsnProGluTyr (NPEY) in its intracytoplasmic domain. To determine if this putative consensus sequence is...

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PMID: 1791832
DOI: 10.1210/mend-5-12-1827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The NPEY sequence is not necessary for endocytosis and processing of insulin-receptor complexes.PMID 1791832Read ↗

Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors.Semantic proximity Read ↗

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.Semantic proximity Read ↗

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.Semantic proximity Read ↗

A domain of the insulin receptor required for endocytosis in rat fibroblasts.Semantic proximity Read ↗

Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.Semantic proximity Read ↗

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.Semantic proximity Read ↗

Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.Semantic proximity Read ↗

Involvement of dileucine motifs in the internalization and degradation of the insulin receptor.Semantic proximity Read ↗

An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor.Semantic proximity Read ↗

Mutational analysis of the N-linked glycosylation sites of the human insulin receptor.Semantic proximity Read ↗

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