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Article

The NPEY sequence is not necessary for endocytosis and processing of insulin-receptor complexes.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 1991

Berhanu P, Ibrahim-Schneck R H, Anderson C, Wood W M

Abstract excerpt

The tetrameric amino acid sequence AsnProXTyr (NPXY), where X represents any amino acid, is conserved in the intracytoplasmic domains of several membrane proteins and has been postulated to play a role in receptor-mediated endocytosis. The human insulin receptor (hIR) contains a single copy of th...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cells, Cultured
Cricetinae
Cricetulus
DNA
Endocytosis
Female
Gene Amplification
Insulin
Iodine Radioisotopes
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ovary

Polymerase Chain Reaction

Protein Sorting Signals

Receptor, Insulin

Source

Identifiers

PMID: 1791832
DOI: 10.1210/mend-5-12-1827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1791832-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The NPEY sequence is not necessary for endocytosis and processing of insulin-receptor complexes.PMID 1791832Read ↗

Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors.Semantic proximity Read ↗

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.Semantic proximity Read ↗

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.Semantic proximity Read ↗

A domain of the insulin receptor required for endocytosis in rat fibroblasts.Semantic proximity Read ↗

Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.Semantic proximity Read ↗

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.Semantic proximity Read ↗

Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.Semantic proximity Read ↗

Involvement of dileucine motifs in the internalization and degradation of the insulin receptor.Semantic proximity Read ↗

An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor.Semantic proximity Read ↗

Mutational analysis of the N-linked glycosylation sites of the human insulin receptor.Semantic proximity Read ↗

Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.Semantic proximity Read ↗

Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells.Semantic proximity Read ↗

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