Article
Loss of tyrosinase activity confers increased skin tumor susceptibility in mice.
Oncogene - 20 May 2004
Saran Anna, Spinola Monica, Pazzaglia Simonetta, Peissel Bernard, Tiveron Cecilia, Tatangelo Laura, Mancuso Mariateresa, Covelli Vincenzo, Giovannelli Lisa, Pitozzi Vanessa, Pignatiello Carmen, Milani Silvano, Dolara Piero, Dragani Tommaso A
Abstract excerpt
The tyrosinase (Tyr) gene encodes the enzyme tyrosinase that catalyses the conversion of L-tyrosine into DOPA (3,4-dihydroxyphenylalanine)-quinone. The albino mutation abrogates functional activity of tyrosinase resulting in deficiency of melanin pigment production in skin and retina. Tyr maps to a region in the central position of Chromosome 7 that contains a skin tumor-modifier locus. We rescued the albino...
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