Mutational mapping of the catalytic activities of human tyrosinase.

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Article

Mutational mapping of the catalytic activities of human tyrosinase.

The Journal of biological chemistry - 25 Nov 1992

Tripathi R K, Hearing V J, Urabe K, Aroca P, Spritz R A

Abstract excerpt

Tyrosinase (EC 1.14.18.1) is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxyphenylalanine (dopa) and the subsequent oxidation of dopa to dopaquinone. It has been proposed that tyrosi...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Exons
HeLa Cells
Humans
Kinetics
Molecular Sequence Data
Monophenol Monooxygenase
Mutagenesis, Site-Directed
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Recombinant Proteins
Temperature
Transfection

Source

Open in PubMed

Identifiers

PMID: 1429711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1429711-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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