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Article

Mutational mapping of the catalytic activities of human tyrosinase.

The Journal of biological chemistry - 25 Nov 1992

Tripathi R K, Hearing V J, Urabe K, Aroca P, Spritz R A

Abstract excerpt

Tyrosinase (EC 1.14.18.1) is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxyphenylalanine (dopa) and the subsequent oxidation of dopa to dopaquinone. It has been proposed that tyrosinase is also able to oxidize 5,6-dihydroxyindole (DHI), a later product in the melanogenic pathway, to...

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PMID: 1429711

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Mutational mapping of the catalytic activities of human tyrosinase.PMID 1429711Read ↗

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Tyrp1 and oculocutaneous albinism type 3.Semantic proximity Read ↗

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