Article
Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice.
Nucleic acids research - 25 Dec 1990
Yokoyama T, Silversides D W, Waymire K G, Kwon B S, Takeuchi T, Overbeek P A
Abstract excerpt
Albinism, due to a lack of melanin pigment, is one of the oldest known mutations in mice. Tyrosinase (monophenol oxygenase, EC 1.14.18.1) is the first enzyme in the pathway for melanin synthesis, and the gene encoding this enzyme has been mapped to the mouse albino (c) locus. We have used mouse tyrosinase cDNA clones and genomic sequencing to study the albino mutation in laboratory mice. Within the tyrosinase...
Topics
- Albinism
- Animals
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- Cysteine
- Female
- Male
- Melanins
- Mice
- Mice, Transgenic
- Molecular Sequence Data