Article
Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice.
The EMBO journal - 1 Sept 1990
Beermann F, Ruppert S, Hummler E, Bosch F X, Müller G, Rüther U, Schütz G
Abstract excerpt
The c-locus of the mouse is thought to encode tyrosinase, the key enzyme for melanin synthesis in melanocytes of the skin and the eye. Recently, a mouse cDNA was isolated and shown to confer tyrosine activity on a cell line which expressed no specialized functions for melanin synthesis. To verify...
Topics
- Albinism
- Amino Acid Sequence
- Animals
- Base Sequence
- Catechol Oxidase
- Genes
- Hair Color
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Molecular Sequence Data
- Monophenol Monooxygenase