Article
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase.
Pigment cell research - 1 Dec 2001
Cohen-Solal K A, Reuhl K R, Ryan K B, Roberts K G, Chen S
Abstract excerpt
Lack of characteristic pigmentation and a wide range of clinical presentations account for the diagnostic challenge associated with amelanotic malignant melanoma. Experimental studies of this important human cancer have been hampered by the lack of an appropriate animal model. We previously described a transgenic mouse line (TG-3) that spontaneously develops pigmented cutaneous melanoma. F1 crosses were generated...
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