Article
Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples.
Lancet (London, England) - 26 Jun 2004
Dorak M Tevfik, Tang Jianming, Penman-Aguilar Ana, Westfall Andrew O, Zulu Isaac, Lobashevsky Elena S, Kancheya Nzali G, Schaen Margaret M, Allen Susan A, Kaslow Richard A
Abstract excerpt
Factors that might increase risk of HIV-1 transmission include age, sex, and amount of HIV-1 RNA in plasma, but findings for HLA allele-sharing are not in agreement. We tested the hypothesis that allele sharing at HLA loci is associated with increased risk of transmission of HIV-1 infection in cohabiting heterosexual Zambian couples. We studied 125 initially serodiscordant partners with sequence-confirmed...
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