Article
Spectrum of p53 tumor suppressor gene mutations and breast cancer survival.
Breast cancer research and treatment - 1 Jan 2004
Lai Hong, Ma Fangchao, Trapido Edward, Meng Lou, Lai Shenghan
Abstract excerpt
CONTEXT: p53 mutation is associated with poor prognosis in breast cancer patients. Mutations in different structural and functional domains of p53 have different effects on its biological activities. Nevertheless, few studies have examined the full spectrum of p53 gene mutations in relation to breast cancer survival. OBJECTIVE: To evaluate the prognostic significance of the types, localizations, and multiplicity...
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