Article
Type of TP53 mutation and ERBB2 amplification affects survival in node-negative breast cancer.
Breast cancer research and treatment - 1 Nov 2007
Ozcelik Hilmi, Pinnaduwage Dushanthi, Bull Shelley B, Andrulis Irene L
Abstract excerpt
Alterations of TP53 and ERBB2 have been shown to play important roles in the prognosis of breast cancer. The primary objective of this study is to characterize TP53 mutation types in node negative breast cancer and investigate their prognostic value, alone and in combination with ERBB2 amplification status. TP53 mutational status (exons 2-10) and ERBB2 amplification status were determined in tumor specimens from...
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