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Article

TP53 Mutations and Outcomes in Breast Cancer: Reading beyond the Headlines.

Trends in cancer - 1 Feb 2020

Shahbandi Ashkan, Nguyen Hoang D, Jackson James G

Abstract excerpt

TP53 is the most frequently mutated gene in breast cancer, but its role in survival is confounded by different studies concluding that TP53 mutations are associated with negative, neutral, or positive outcomes. Closer examination showed that many studies were limited by factors such as imprecise methods to detect TP53 mutations and small cohorts that combined patients treated with drugs having very different...

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Identifiers

PMID: 32061310
DOI: 10.1016/j.trecan.2020.01.007
PMCID: PMC7931175

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