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Article

Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies.

Journal of computer-aided molecular design - 1 Apr 2011

Lee Jin Hee, Lee Yoonji, Ryu HyungChul, Kang Dong Wook, Lee Jeewoo, Lazar Jozsef, Pearce Larry V, Pavlyukovets Vladimir A, Blumberg Peter M, Choi Sun

Abstract excerpt

The transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel composed of four monomers with six transmembrane helices (TM1-TM6). TRPV1 is found in the central and peripheral nervous system, and it is an important therapeutic target for pain relief. We describe here the construction of a tetrameric homology model of rat TRPV1 (rTRPV1). We experimentally evaluated by mutational...

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Identifiers

PMID: 21448716
DOI: 10.1007/s10822-011-9421-5
PMCID: PMC3420359

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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