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Article

Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study.

PloS one - 1 Jan 2016

Ohbuchi Katsuya, Mori Yoshikazu, Ogawa Kazuo, Warabi Eiji, Yamamoto Masahiro, Hirokawa Takatsugu

Abstract excerpt

Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel and a multimodal sensor protein. Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been extensively characterized; however, detailed information on the binding mode of other vanilloids remains lacking. In...

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Source

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Identifiers

PMID: 27606946
DOI: 10.1371/journal.pone.0162543
PMCID: PMC5015962

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study.PMID 27606946Read ↗

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