Article
20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel.
The Journal of biological chemistry - 20 Apr 2012
Wen Hairuo, Östman Johan, Bubb Kristen J, Panayiotou Catherine, Priestley John V, Baker Mark D, Ahluwalia Amrita
Abstract excerpt
TRPV1 is a member of the transient receptor potential ion channel family and is gated by capsaicin, the pungent component of chili pepper. It is expressed predominantly in small diameter peripheral nerve fibers and is activated by noxious temperatures >42 °C. 20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P-450 4A/4F-derived metabolite of the membrane phospholipid arachidonic acid. It is a powerful...
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