Article
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.
Pain - 1 Nov 2000
Hayes Philip, Meadows Helen J, Gunthorpe Martin J, Harries Mark H, Duckworth Malcolm D, Cairns William, Harrison David C, Clarke Catherine E, Ellington Kathryn, Prinjha Rab K, Barton Amanda J L, Medhurst Andrew D, Smith Graham D, Topp Simon, Murdock Paul, Sanger Gareth J, Terrett John, Jenkins Owen, Benham Christopher D, Randall Andrew D, Gloger Isro S, Davis John B
Abstract excerpt
Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we describe the cloning of a human vanilloid receptor-1 (hVR1) cDNA containing a 2517 bp open reading frame that encodes a protein with 92% homology to the rat vanilloid receptor-1. Oocytes or...
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