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Article

A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents.

Molecular and cellular neurosciences - 1 Jun 2003

Mohapatra Durga Prasanna, Wang Sho-Ya, Wang Ging Kuo, Nau Carla

Abstract excerpt

The Vanilloid Receptor TRPV1 is a non-selective cation channel with a high relative Ca(2+) permeability. TRPV1 exhibits slow desensitization, a potential mechanism regulating adaptation of peripheral sensory neurons to noxious stimuli. The predicted folding pattern of TRPV1 resembles that of voltage-gated channels. Sequence alignment of segments 6 of TRPV1 and voltage-gated Na(+) channels reveals a conserved...

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Source

Identifiers

PMID: 12812762
DOI: 10.1016/s1044-7431(03)00054-x

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents.PMID 12812762Read ↗

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