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Article

A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a target.

Genetics - 1 Aug 2001

Lee L A, Elfring L K, Bosco G, Orr-Weaver T L

Abstract excerpt

The early cell cycles of Drosophila embryogenesis involve rapid oscillations between S phase and mitosis. These unique S-M cycles are driven by maternal stockpiles of components necessary for DNA replication and mitosis. Three genes, pan gu (png), plutonium (plu), and giant nuclei (gnu) are required to control the cell cycle specifically at the onset of Drosophila development by inhibiting DNA replication and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11514446
DOI: 10.1093/genetics/158.4.1545
PMCID: PMC1461742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a target.PMID 11514446Read ↗

PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development.Semantic proximity Read ↗

The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions.Semantic proximity Read ↗

giant nuclei is essential in the cell cycle transition from meiosis to mitosis.Semantic proximity Read ↗

Drosophila PLUTONIUM protein is a specialized cell cycle regulator required at the onset of embryogenesis.Semantic proximity Read ↗

The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization.Semantic proximity Read ↗

Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth.Semantic proximity Read ↗

A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans.Semantic proximity Read ↗

SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.Semantic proximity Read ↗

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The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18.Semantic proximity Read ↗

Myc-dependent cell competition and proliferative response requires induction of the ribosome biogenesis regulator Peter PanSemantic proximity Read ↗

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Semantic proximity Read ↗

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