Article
Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo.
Cell biology international - 1 Feb 2013
Dubatolova Tatiana D, Volkova Elena I, Omelyanchuk Leonid V
Abstract excerpt
Pioneering single gene study documents pre-mRNA processing proteins participation in the cell-cycle regulation of multi-cellular animals (Andersen and Tapon, 2008, J Biol Chem 283: 31256-67). Whole-genome RNAi screen in Drosophila tissue-culture cell lines demonstrates that 17 genes involved in RNA-processing are required for G2/M check-point function (Kondo and Perrimon, 2011, Sci Signal 4: rs1). In particular,...
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