Article
Mutation frequencies but not mutant frequencies in Big Blue mice fit a Poisson distribution.
Environmental and molecular mutagenesis - 1 Jan 1996
Nishino H, Schaid D J, Buettner V L, Haavik J, Sommer S S
Abstract excerpt
Transgenic mutation assays generally use mutant frequencies to estimate mutation frequencies but the degree to which clonal expansion inflates mutant frequencies is largely unknown. Mutant frequency is defined as the fraction of cells carrying mutations in the gene of interest and, according to t...
Topics
- Age Factors
- Animals
- Brain
- Male
- Mice
- Mice, Transgenic
- Models, Genetic
- Mutation
- Poisson Distribution
- Thymus Gland