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Article

A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.

PloS one - 1 Jan 2013

Ambjørn Malene, Dubreuil Véronique, Miozzo Federico, Nigon Fabienne, Møller Bente, Issazadeh-Navikas Shohreh, Berg Jacob, Lees Michael, Sap Jan

Abstract excerpt

Alterations in function of the neurotrophin BDNF are associated with neurodegeneration, cognitive decline, and psychiatric disorders. BDNF promotes axonal outgrowth and branching, regulates dendritic tree morphology and is important for axonal regeneration after injury, responses that largely result from activation of its tyrosine kinase receptor TrkB. Although intracellular neurotrophin (NT) signaling presumably...

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Source

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Identifiers

PMID: 23785422
DOI: 10.1371/journal.pone.0065371
PMCID: PMC3681791

Genes

BDNF
PTPN12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.PMID 23785422Read ↗

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Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells.Semantic proximity Read ↗

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