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Article

NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells.

Journal of neurochemistry - 1 Dec 2008

Wang Jiz-Yuh, Yang Chi-Hwa, Yeh Chi-Ling, Lin Chia-Hua, Chen Yi-Rong

Abstract excerpt

Neuroendocrine-associated phosphatase (NEAP), an atypical dual specificity phosphatase is preferentially expressed in neuroendocrine cells. In this study we found that NEAP, but not NEAP-(C152S) mutant, evidently reduced epidermal growth factor (EGF) receptor (EGFR) downstream signaling, and impa...

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Source

Identifiers

PMID: 19014381
DOI: 10.1111/j.1471-4159.2008.05714.x

Genes

EGFR
EGF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19014381-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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