Article
Linkage of interactions in sickle hemoglobin fiber assembly: inhibitory effect emanating from mutations in the AB region of the alpha-chain is annulled by a mutation at its EF corner.
The Journal of biological chemistry - 7 May 2004
Sudha Rajamani, Anantharaman Lavanya, Sivaram Mylavarapu V S, Mirsamadi Neda, Choudhury Devapriya, Lohiya Nirmal K, Gupta Rasik B, Roy Rajendra P
Abstract excerpt
The AB and GH regions of the alpha-chain are located in spatial proximity and contain a cluster of intermolecular contact residues of the sickle hemoglobin (HbS) fiber. We have examined the role of dynamics of AB/GH region on HbS polymerization through simultaneous replacement of non-contact Ala(19) and Ala(21) of the AB corner with more flexible Gly or rigid alpha-aminoisobutyric acid (Aib) residues. The...
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