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Article

Beta7E-beta132K salt bridge and sickle haemoglobin stability and conformation.

British journal of haematology - 1 Jul 2003

Fablet Christophe, Chen Qiuying, Baudin-Creuza Véronique, Marden Michael C, Nagel Ronald L, Pagnier Josée, Hirsch Rhoda Elison

Abstract excerpt

The liganded (R-state) form of sickle cell haemoglobin (HbS) is of particular relevance at non-polymerizing concentrations as oxy HbS exhibits unusual properties compared with oxy HbA: mechanical precipitability (resulting from surface denaturation), greater unfolding at an air-water interface and a tendency to oxidize more readily. In human haemoglobins, the beta7 (A4) Glu residue forms an intrachain salt bridge...

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Source

Identifiers

PMID: 12846903
DOI: 10.1046/j.1365-2141.2003.04432.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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