Article
Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis.
Tissue antigens - 1 Mar 2004
Harbo H F, Lie B A, Sawcer S, Celius E G, Dai K-Z, Oturai A, Hillert J, Lorentzen A R, Laaksonen M, Myhr K-M, Ryder L P, Fredrikson S, Nyland H, Sørensen P S, Sandberg-Wollheim M, Andersen O, Svejgaard A, Edland A, Mellgren S I, Compston A, Vartdal F, Spurkland A
Abstract excerpt
In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ...
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