Article
Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability.
Gastroenterology - 1 Jul 2005
Schulmann Karsten, Mori Yuriko, Croog Victoria, Yin Jing, Olaru Andreea, Sterian Anca, Sato Fumiaki, Wang Suna, Xu Yan, Deacu Elena, Berki Agnes T, Hamilton James P, Kan Takatsugu, Abraham John M, Schmiegel Wolff, Harpaz Noam, Meltzer Stephen J
Abstract excerpt
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) are at increased risk of developing colorectal cancer (CRC). We sought to determine the frequency of high-level microsatellite instability (MSI-H) and the mutational and methylation profile of MSI-H IBD-related neoplasms (IBDNs). METHODS: A total of 124 IBDNs (81 cancers, 43 dysplasias) from 78 patients were studied for the frequency of MSI-H and...
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