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Article

Impaired IgA class switching in APRIL-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2004

Castigli Emanuela, Scott Sumi, Dedeoglu Fatma, Bryce Paul, Jabara Haifa, Bhan Atul K, Mizoguchi Emiko, Geha Raif S

Abstract excerpt

The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in immunity, we generated APRIL-deficient mice. APRIL(-/-) mice have normal T and B lymphocyte development, normal T and B cell proliferation in vitro, but increased numbers of CD44(hi)CD62L(lo) CD4(+) effector/memory T cells and increased IgG responses to...

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Identifiers

PMID: 14988498
DOI: 10.1073/pnas.0307348101
PMCID: PMC374342

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired IgA class switching in APRIL-deficient mice.PMID 14988498Read ↗

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