Immunological phenotype of the murine Lrba knockout

Abstract excerpt

Biallelic mutations in the human lipopolysaccharide responsive beige‐like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the phenotypic heterogeneity in patients and the severity of the disease, our aim was to assess the role...

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