Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching

1 Nov 2003

Abstract excerpt

By substituting the H chain C region of IgM with that of IgG, IgA, or IgE, class switching enables Abs to acquire new effector functions that are crucial for the neutralization of invading pathogens. Class switching occurs through class switch DNA recombination (CSR) and usually requires engagement of CD40 on B cells by CD40 ligand on Ag-activated CD4(+) T cells. CSR must be tightly regulated because abnormal IgG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14607922
DOI: 10.4049/jimmunol.171.10.5215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class SwitchingPMID 14607922Read ↗

LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.Semantic proximity Read ↗

Class switch recombination: a friend and a foe.Semantic proximity Read ↗

Differential B‐lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1Semantic proximity Read ↗

Latent Membrane Protein 1, the EBV-Encoded Oncogenic Mimic of CD40, Accelerates Autoimmunity in B6.Sle1 MiceSemantic proximity Read ↗

Multiple carboxyl-terminal regions of the EBV oncoprotein, latent membrane protein 1, cooperatively regulate signaling to B lymphocytes via TNF receptor-associated factor (TRAF)-dependent and TRAF-independent mechanisms.Semantic proximity Read ↗

Immunoglobulin class switch recombination deficiency type 1 or CD40 ligand deficiency: from bedside to bench and back againSemantic proximity Read ↗

Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseasesSemantic proximity Read ↗

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1Semantic proximity Read ↗

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1Semantic proximity Read ↗

IL-21-STAT3 axis negatively regulates LAIR1 expression in B cellsSemantic proximity Read ↗

Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B CellsSemantic proximity Read ↗

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8 <sup>+</sup> T cell responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.