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Article

Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.

Molecular endocrinology (Baltimore, Md.) - 1 May 2004

Nica Gabriela, Herzog Wiebke, Sonntag Carmen, Hammerschmidt Matthias

Abstract excerpt

The Pou domain transcription factor Pit-1 is required for lineage determination and cellular commitment processes during mammalian adenohypophysis development. Here we report the cloning and mutational analysis of a pit1 homolog from zebrafish. Compared with mouse, zebrafish pit1 starts to be expressed at a much earlier stage of adenohypophysis development. However, as in the mouse, expression is restricted to a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14988429
DOI: 10.1210/me.2003-0377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.PMID 14988429Read ↗

Genetic analysis of adenohypophysis formation in zebrafish.Semantic proximity Read ↗

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Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.Semantic proximity Read ↗

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The Ames dwarf gene is required for Pit-1 gene activation.Semantic proximity Read ↗

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Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis.Semantic proximity Read ↗

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