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Article

The Ames dwarf gene is required for Pit-1 gene activation.

Developmental biology - 1 Dec 1995

Andersen B, Pearse R V, Jenne K, Sornson M, Lin S C, Bartke A, Rosenfeld M G

Abstract excerpt

The tissue-specific POU domain transcription factor Pit-1 is required for phenotypic specification of three cell types in the anterior pituitary gland of mammals: somatotropes, thyrotropes, and lactotropes. Mutations in the Pit-1 gene, as first described in Snell and Jackson dwarf (dw) mice, led to pituitary hypoplasia due to lack of these three cell types, as well as hypothyroidism and dwarfism because of...

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Source

Identifiers

PMID: 8612966
DOI: 10.1006/dbio.1995.8040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Ames dwarf gene is required for Pit-1 gene activation.PMID 8612966Read ↗

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.Semantic proximity Read ↗

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.Semantic proximity Read ↗

The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation.Semantic proximity Read ↗

Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope.Semantic proximity Read ↗

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.Semantic proximity Read ↗

Transcriptional mechanisms in anterior pituitary cell differentiation.Semantic proximity Read ↗

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.Semantic proximity Read ↗

Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis.Semantic proximity Read ↗

Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.Semantic proximity Read ↗

All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors.Semantic proximity Read ↗

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.Semantic proximity Read ↗

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