Article
The Ames dwarf gene is required for Pit-1 gene activation.
Developmental biology - 1 Dec 1995
Andersen B, Pearse R V, Jenne K, Sornson M, Lin S C, Bartke A, Rosenfeld M G
Abstract excerpt
The tissue-specific POU domain transcription factor Pit-1 is required for phenotypic specification of three cell types in the anterior pituitary gland of mammals: somatotropes, thyrotropes, and lactotropes. Mutations in the Pit-1 gene, as first described in Snell and Jackson dwarf (dw) mice, led...
Topics
- Animals
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Mice
- Mice, Mutant Strains
- Mutation
- Pituitary Gland
- Transcription Factor Pit-1
- Transcription Factors
- Transcriptional Activation