Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis.

Developmental biology - 1 Apr 2006

Nica Gabriela, Herzog Wiebke, Sonntag Carmen, Nowak Matthias, Schwarz Heinz, Zapata Agustin G, Hammerschmidt Matthias

Abstract excerpt

The homeodomain transcription factor Six1 and its modulator, the protein phosphatase Eya1, cooperate to promote cell differentiation and survival during mouse organ development. Here, we studied the effects caused by loss of eya1 and six1 function on pituitary development in zebrafish. eya1 and six1 are co-expressed in all adenohypophyseal cells. Nevertheless, eya1 (aal, dog) mutants show lineage-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone
Share to LIM-Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pituitary Gland, Anterior

Share to Pro-Opiomelanocortin

Share to Protein Tyrosine Phosphatases

Share to Thyrotropin

Share to Transcription Factor Pit-1

Share to Zebrafish Proteins

Source

Identifiers

PMID: 16458879
DOI: 10.1016/j.ydbio.2005.12.036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis.PMID 16458879Read ↗

Genetic analysis of adenohypophysis formation in zebrafish.Semantic proximity Read ↗

The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis.Semantic proximity Read ↗

The Eyes Absent proteins in development and in developmental disorders.Semantic proximity Read ↗

EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear.Semantic proximity Read ↗

Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.Semantic proximity Read ↗

The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6.Semantic proximity Read ↗

The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line.Semantic proximity Read ↗

Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes.Semantic proximity Read ↗

The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.Semantic proximity Read ↗

Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmesSemantic proximity Read ↗

Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary.Semantic proximity Read ↗

EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.