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Article

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

Nature - 11 Oct 1990

Li S, Crenshaw E B, Rawson E J, Simmons D M, Swanson L W, Rosenfeld M G

Abstract excerpt

Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is...

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PMID: 1977085
DOI: 10.1038/347528a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.PMID 1977085Read ↗

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

The Ames dwarf gene is required for Pit-1 gene activation.Semantic proximity Read ↗

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.Semantic proximity Read ↗

[From gene to disease; POU1F1- and PROP1-mutations in pituitary hormone deficiency].Semantic proximity Read ↗

POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease*Semantic proximity Read ↗

The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation.Semantic proximity Read ↗

Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope.Semantic proximity Read ↗

Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.Semantic proximity Read ↗

Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis.Semantic proximity Read ↗

All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors.Semantic proximity Read ↗

Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.Semantic proximity Read ↗

Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.Semantic proximity Read ↗

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