Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

doi:10.1038/347528a0

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Article

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

Nature - 11 Oct 1990

Li S, Crenshaw E B, Rawson E J, Simmons D M, Swanson L W, Rosenfeld M G

Abstract excerpt

Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is...

Topics

Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
DNA-Binding Proteins
Dwarfism, Pituitary
Gene Expression
Genes, Homeobox
Growth Hormone
Mice
Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Phenotype

Pituitary Gland, Anterior

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1977085
DOI: 10.1038/347528a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1977085-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.PMID 1977085Read ↗

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