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Article

Pitx2is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification

15 Jan 2002

Abstract excerpt

Analysis of an allelic series in mice revealed that the Pitx2 homeobox gene is required at multiple stages of pituitary development. It is necessary for initiating expansion of Rathke's pouch and maintaining expression of the fetal-specific transcription factors Hesx1 and Prop1. At later stages Pitx2 is necessary for specification and expansion of the gonadotropes and Pit1 lineage within the ventral and...

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PMID: 11807026
DOI: 10.1242/dev.129.2.329

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