Article
Pituitary transcription factors: from congenital deficiencies to gene therapy.
Journal of neuroendocrinology - 1 Sept 2006
Quentien M H, Barlier A, Franc J L, Pellegrini I, Brue T, Enjalbert A
Abstract excerpt
Despite the existence of interspecies phenotypic variability, animal models have yielded valuable insights into human pituitary diseases. Studies on Snell and Jackson mice known to have growth hormone, prolactin and thyroid-stimulating hormone deficiencies involving the hypoplastic pituitary gland have led to identifying alterations of the pituitary specific POU homeodomain Pit-1 transcription factor gene. The...
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