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Article

Candidate genes for panhypopituitarism identified by gene expression profiling.

Physiological genomics - 6 Oct 2011

Mortensen Amanda H, MacDonald James W, Ghosh Debashis, Camper Sally A

Abstract excerpt

Mutations in the transcription factors PROP1 and PIT1 (POU1F1) lead to pituitary hormone deficiency and hypopituitarism in mice and humans. The dysmorphology of developing Prop1 mutant pituitaries readily distinguishes them from those of Pit1 mutants and normal mice. This and other features suggest that Prop1 controls the expression of genes besides Pit1 that are important for pituitary cell migration, survival,...

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Share to Homeodomain Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21828248
DOI: 10.1152/physiolgenomics.00080.2011
PMCID: PMC3217323

Genes

PROP1

Provenance

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