Article
Histone H1 variants differentially inhibit DNA replication through an affinity for chromatin mediated by their carboxyl-terminal domains.
Gene - 12 Jun 2002
De Siddhartha, Brown David T, Lu Zhi Hong, Leno Gregory H, Wellman Susan E, Sittman Donald B
Abstract excerpt
Multiple forms of histone H1 are found in most mammalian tissues, and diversity in their temporal and spatial expression likely corresponds to diversity in function. Here, using Xenopus egg extracts, we show that while the somatic H1s significantly inhibit DNA replication in Xenopus sperm nuclei, little or no inhibition is seen in the case of the testes-specific variant, H1t. We suggest that differences in...
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