Article
Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome.
Biochemistry - 12 Apr 2016
Yue Hongjun, Fang He, Wei Sijie, Hayes Jeffrey J, Lee Tae-Hee
Abstract excerpt
Linker histone H1 regulates chromatin structure and gene expression. Investigating the dynamics and stoichiometry of binding of H1 to DNA and the nucleosome is crucial to elucidating its functions. Because of the abundant positive charges and the strong self-affinity of H1, quantitative in vitro studies of its binding to DNA and the nucleosome have generated results that vary widely and, therefore, should be...
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