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Article

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

The Journal of biological chemistry - 7 May 2004

Gafni Juliette, Hermel Evan, Young Jessica E, Wellington Cheryl L, Hayden Michael R, Ellerby Lisa M

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine (polyQ) tract expansion near the N terminus of huntingtin (Htt). Proteolytic processing of mutant Htt and abnormal calcium signaling may play a critical role in disease progression and pathogenesis. Recent work indicates that calpains may participate in the increased and/or altered patterns of Htt proteolysis leading to the...

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Source

Identifiers

PMID: 14981075
DOI: 10.1074/jbc.M401267200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.PMID 14981075Read ↗

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.Semantic proximity Read ↗

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.Semantic proximity Read ↗

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.Semantic proximity Read ↗

Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.Semantic proximity Read ↗

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.Semantic proximity Read ↗

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearanceSemantic proximity Read ↗

Huntington's disease: molecular basis of neurodegeneration.Semantic proximity Read ↗

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.Semantic proximity Read ↗

Huntingtin processing in pathogenesis of Huntington disease.Semantic proximity Read ↗

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease.Semantic proximity Read ↗

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.Semantic proximity Read ↗

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.Semantic proximity Read ↗

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