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Article

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.

Human molecular genetics - 1 Aug 2008

Warby Simon C, Doty Crystal N, Graham Rona K, Carroll Jeffrey B, Yang Yu-Zhou, Singaraja Roshni R, Overall Christopher M, Hayden Michael R

Abstract excerpt

Proteolysis of mutant huntingtin is crucial to the development of Huntington disease (HD). Specifically preventing proteolysis at the capase-6 (C6) consensus sequence at amino acid 586 of mutant huntingtin prevents the development of behavioural, motor and neuropathological features in a mouse model of HD. However, the mechanism underlying the selective toxicity of the 586 amino acid cleavage event is currently...

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PMID: 18445618
DOI: 10.1093/hmg/ddn139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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