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Article

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.

Molecular cell - 1 Aug 2002

Lunkes Astrid, Lindenberg Katrin S, Ben-Haïem Léa, Weber Chantal, Devys Didier, Landwehrmeyer G Bernhard, Mandel Jean-Louis, Trottier Yvon

Abstract excerpt

Proteolytic processing of mutant huntingtin (mhtt) is regarded as a key event in the pathogenesis of Huntington's disease (HD). Mhtt fragments containing a polyglutamine expansion form intracellular inclusions and are more cytotoxic than full-length mhtt. Here, we report that two distinct mhtt fragments, termed cp-A and cp-B, differentially build up nuclear and cytoplasmic inclusions in HD brain and in a cellular...

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Source

Identifiers

PMID: 12191472
DOI: 10.1016/s1097-2765(02)00602-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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