Article
Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Neurobiology of disease - 1 Feb 2006
Tanaka Yuji, Igarashi Shuichi, Nakamura Masayuki, Gafni Juliette, Torcassi Cameron, Schilling Gabrielle, Crippen Danielle, Wood Jonathan D, Sawa Akira, Jenkins Nancy A, Copeland Neal G, Borchelt David R, Ross Christopher A, Ellerby Lisa M
Abstract excerpt
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilitate studies of pathogenesis and therapeutics, w...
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