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Article

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.

Neuron - 29 Jul 2010

Miller John P, Holcomb Jennifer, Al-Ramahi Ismael, de Haro Maria, Gafni Juliette, Zhang Ningzhe, Kim Eugene, Sanhueza Mario, Torcassi Cameron, Kwak Seung, Botas Juan, Hughes Robert E, Ellerby Lisa M

Abstract excerpt

Proteolytic cleavage of huntingtin (Htt) is known to be a key event in the pathogenesis of Huntington's disease (HD). Our understanding of proteolytic processing of Htt has thus far focused on the protease families-caspases and calpains. Identifying critical proteases involved in Htt proteolysis and toxicity using an unbiased approach has not been reported. To accomplish this, we designed a high-throughput...

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Identifiers

PMID: 20670829
DOI: 10.1016/j.neuron.2010.06.021
PMCID: PMC3098887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.PMID 20670829Read ↗

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