Article
N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease.
Cell cycle (Georgetown, Tex.) - 1 Dec 2007
Ratovitski Tamara, Nakamura Masayuki, D'Ambola James, Chighladze Ekaterine, Liang Yideng, Wang Wenfei, Graham Rona, Hayden Michael R, Borchelt David R, Hirschhorn Ricky R, Ross Christopher A
Abstract excerpt
Proteolytic cleavage of mutant huntingtin may play a key role in the pathogenesis of Huntington's disease; however the steps in huntingtin proteolysis are not fully understood. Huntingtin was shown to be cleaved by caspases and calpains within a region between 460-600 amino acids from the N-terminus. Two smaller N-terminal fragments produced by unknown protease have been previously described as cp-A and cp-B. To...
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