Article

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance

2017-12-13

Abstract excerpt

<h4>ABSTRACT</h4> Huntington disease (HD) is a progressive neurodegenerative disease that initially affects the striatum leading to changes in behavior and loss of motor coordination. It is caused by an expansion in the polyglutamine repeat at the N-terminus of huntingtin (HTT) that leads to aggregation of mutant HTT. The loss of wildtype function, in combination with the toxic gain of function mutation, initiate...

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Literature Corpus work: ac3ccd10-5784-5b8e-aa0f-1b5289a9a609
DOI: 10.1101/232827

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