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Article

Huntingtin processing in pathogenesis of Huntington disease.

Acta pharmacologica Sinica - 1 Oct 2004

Qin Zheng-Hong, Gu Zhen-Lun

Abstract excerpt

Huntingtons disease (HD) is caused by an expansion of the polyglutamine tract in the protein named huntingtin. The expansion of polyglutamine tract induces selective degeneration of striatal projection neurons and cortical pyramidal neurons. The bio-hallmark of HD is the formation of intranuclear inclusions and cytoplasmic aggregates in association with other cellular proteins in vulnerable neurons. Accumulation...

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PMID: 15456523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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