Article
A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint.
Chromosoma - 1 Sept 2001
Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y
Abstract excerpt
The centromere is crucial for the proper segregation of chromosomes in all eukaryotic cells. We identified a centromeric protein, Nuf2, which is conserved in fission yeast, human, nematode, and budding yeast. Gene disruption of nuf2+ in the fission yeast Schizosaccharomyces pombe caused defects in chromosome segregation and the spindle checkpoint: the mitotic spindle elongated without segregating the chromosomes,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.