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Article

Direct interaction of geminin and Six3 in eye development.

Nature - 19 Feb 2004

Del Bene Filippo, Tessmar-Raible Kristin, Wittbrodt Joachim

Abstract excerpt

Organogenesis in vertebrates requires the tight control of cell proliferation and differentiation. The homeobox-containing transcription factor Six3 plays a pivotal role in the proliferation of retinal precursor cells. In a yeast two-hybrid screen, we identified the DNA replication-inhibitor geminin as a partner of Six3. Geminin inhibits cell-cycle progression by sequestering Cdt1 (refs 4, 5), the key component...

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PMID: 14973488
DOI: 10.1038/nature02292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct interaction of geminin and Six3 in eye development.PMID 14973488Read ↗

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Semantic proximity Read ↗

Geminin is essential for the development of preimplantation mouse embryosSemantic proximity Read ↗

Geminin prevents rereplication during xenopus development.Semantic proximity Read ↗

Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition.Semantic proximity Read ↗

Six3 and Six6 jointly regulate the identities and developmental trajectories of multipotent retinal progenitor cells in the mouse retinaSemantic proximity Read ↗

GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication.Semantic proximity Read ↗

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.Semantic proximity Read ↗

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.Semantic proximity Read ↗

G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis.Semantic proximity Read ↗

Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.Semantic proximity Read ↗

Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.Semantic proximity Read ↗

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